Rosie O’Donnell Looks in the Mirror, Yells “WHO IS SHE?!” After Mounjaro Glow-Up

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Rosie O’Donnell, 63 years fabulous and now suspiciously smaller, just dropped a photo bomb on Instagram that has fans clutching their pearls and their Mounjaro prescriptions. In her Friday post (May 23), Rosie served svelte comedy queen realness, standing onstage in a cozy sweater and pants, mic in hand, looking like she just stepped off the set of a Weight Watchers commercial directed by Wes Anderson.

Her caption? β€œI can’t believe this is me now.”
Honestly, same, Rosie. SAME.

Naturally, she blessed us with hashtags too: #mounjaro, #weightloss, and the ever-relatable #bodydismorphia β€” because apparently, even famous people can’t believe what’s going on with their reflection in the Zara dressing room mirror.

ICYMI, Mounjaro is that hot new Type 2 diabetes med that moonlights as a celebrity weight loss secret weapon β€” a cousin to Ozempic and Wegovy. Basically, it’s the β€œKeto” of injections, minus the bacon.

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Rosie’s not gatekeeping, though. A few months ago, she spilled the tea on TikTok:

β€œI’ve lost more weight. I am on Mounjaro for my diabetes, and one of the side effects is you lose weight.”

Side effect? More like main character energy.

But wait, there’s more. Rosie also confessed she’s living that DIY lifestyle these days. Gone is the L.A. chef (RIP luxury). Now, she’s personally whipping up meals for herself and her son Clay, proving that even former daytime TV royalty can get down in the kitchen β€” or at least microwave something enthusiastically.

After moving to Ireland (because why not pivot from comedy to Celtic living?), Rosie had to go clothes shopping in Dublin because nothing in her closet fit anymore. We imagine her in the dressing room whispering, β€œLarge? Just large? Where’s the rest of it?!”

β€œI’m one of those people who always had a weight issue,” she shared. β€œNow that I’m a size large β€” instead of XL or XXL β€” I find it shocking.”

Honestly, if β€œLarge” is the new β€œWait… is that Rosie O’Donnell or someone cosplaying her from the ’90s?” then we fully support it.

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Back in January 2023, Rosie said her doc had her on both Mounjaro and Repatha (a cholesterol med β€” because why have one health glow-up when you can have two?). She also cut back on sugar (RIP cupcakes), and started moving more, which we assume includes running to grab the remote or enthusiastically dancing when Clay puts on a TikTok playlist.

β€œMy appetite has decreased significantly,” she said, crediting the meds and, presumably, the fact that Irish snacks don’t hit quite like American junk food.

So here we are. Rosie O’Donnell is slimmer, snarkier, and serving β€œbefore and after” realness. Someone give her a cooking show, a fashion line, or at least a trophy that says β€œBest Use of Hashtags by a Comedian in 2025.”

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